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athensresearch 16-14-051200說(shuō)明書(shū)——上海起發(fā)

更新時(shí)間:2024-01-12      點(diǎn)擊次數(shù):431


Athens Research & Technology是成立于2010年的新興生物高科技制品公司,該公司擁有BSL-2實(shí)驗(yàn)室及超過(guò)11000平方英尺的cGMP生產(chǎn)廠房,并且通過(guò)ISO 9001:2008認(rèn)證。Athens公司致力于純化分離高純度,高活性的人類蛋白質(zhì)及研發(fā)多克隆抗血清產(chǎn)品。提供包括高純度及活性的絲氨酸蛋白酶,蛋白酶抑制劑,中性粒細(xì)胞酶,載脂蛋白,脂蛋白,血小板蛋白,轉(zhuǎn)鐵蛋白,免疫球蛋白等等。公司產(chǎn)品適用于炎癥,冠狀動(dòng)脈疾病,自身免疫性疾病,癌癥,阿爾茨海默氏病等眾多研究領(lǐng)域,已被世界*制藥公司及診斷試劑公司用于體外診斷試劑盒/免疫檢測(cè)試劑盒、藥物篩選、細(xì)胞培養(yǎng)液(包括干細(xì)胞)等產(chǎn)品研發(fā)。除了人類蛋白質(zhì),我們還從動(dòng)物血清和組織中分離多種蛋白質(zhì)及酶類。此外,Athens Research and Technology還提供特殊試劑/蛋白定制服務(wù),以滿足研究人員的不同需求。


athensresearch 16-14-051200說(shuō)明書(shū)——上海起發(fā)


Elastase, Human Neutrophil


MW:29500

消光系數(shù):0.985

無(wú)鹽凍干固體。

重組:離心后,我們建議將50mM醋酸鈉(pH 5.5)和150mM NaCl加入到原始體積中,然后輕輕混合以確保充分均質(zhì)。

儲(chǔ)存:<=-20°C

這種酶降解彈性蛋白、膠原蛋白和蛋白多糖,并與肺動(dòng)脈塞和類風(fēng)濕性關(guān)節(jié)炎的發(fā)展有關(guān)。

參考:Baugh,R.J.和Travis,J.1976。生物化學(xué)15,836;Bode,W.等人,1986年。EMBO J.5(10),2453

活性:每毫克蛋白質(zhì)20-22個(gè)單位。一個(gè)單位被定義為在25攝氏度、pH 7.5下每分鐘水解一摩爾MeO-Suc-Ala-Ala-Pro-Val-pNA的酶的量。

純度:SDS-PAGE顯示>=95%

由經(jīng)美國(guó)食品藥品監(jiān)督管理局要求的檢測(cè)顯示對(duì)HBsAg、抗-HCV、抗-HBc無(wú)反應(yīng)且抗-HIV 1和2呈陰性的全血制備。

雅典研究與技術(shù)公司的產(chǎn)品是實(shí)驗(yàn)室試劑,不得用于人體或任何藥物用途



Kerros C, et al.
Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells.
J Biol Chem. 2017 Jun 16;292(24):10295-10305. doi: 10.1074/jbc.M116.773051. Epub 2017 May 3.

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Leukocyte Protease Binding to Nucleic Acids Promotes Nuclear Localization and Cleavage of Nucleic Acid Binding Proteins.
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